top of page
Search

New paper alert

Very pleased to see the publication of the results of an outstanding collaborative projects with Gkogkas group at Foundation for Research & Technology Hellas and Khoutorsky group at McGill University in the Journal Brain.


In this paper, entitled "Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1”, by investigating the phosphoproteome regulated by Mnk kinases, we revealed a novel mechanism of translational control in brain implicating Mnk kinases and the autism risk gene Syngap1 in regulating memory and autism-related behaviours.

More specifically,

- We show that downstream of the MAPK pathway, Mnk1/2 are required for synaptic plasticity (LTP), learning and memory formation using a transgenic knockout model.

- We define the total and synaptic translatome regulated by Mnk1/2 using ribosome profiling.

- We define the Mnk1/2-regulated total and synaptic phosphoproteome in mouse brain, revealing a pervasive regulation of synaptic proteins and autism risk genes, including Syngap1 (S788).

- We show that Mnk1, the predominant Mnk in brain, binds to Syngap1 and that phosphorylation of Syngap1 S788 by Mnks promotes protein synthesis.

- Finally, we further elaborate the Mnk-Syngap1 link by rescue experiments in transgenic mice correcting memory deficits, social behaviour and mTORC1 signalling.

Recent Posts

See All

Celebrating Tom and Okan's New Review Paper

We are excited by the publication of a new review paper by our very own Tom and Okan in the FEBS Journal. This paper, titled "Dysregulated Ribosome Quality Control in Human Diseases" delves into the c

New paper alert!

We are thrilled to see the new paper by our collaborator Costa's group, featuring our very own postdoc Parisa as a contributor! This paper reports an exciting mechanism of regulation of sprouting angi

Comentários


bottom of page