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Publications

2023

Chatterjee S, Naeli P, Simms N, Garzia A, Hackett A, Coyle K, Harris Snell P, McGirr T, Sawant TN, Dang K, Stoichkova ZV, Alain T, Tuschl T, McDade SS, Longley DB, Gkogkas CG, Adrain C, Knight JRP, Jafarnejad SM. Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil. bioRxiv. 2023 Dec 26. doi: https://doi.org/10.1101/2023.12.26.573247.

Choi JH, Luo J, Hesketh GG, Guo S, Pistofidis A, Ladak RJ, An Y2, Alain T, Schmeing TM, Gingras AC, Duchaine T, Zhang X*, Sonenberg N*, Jafarnejad SM*. Repression of mRNA Translation Initiation by GIGYF1 via Blocking the eIF3-eIF4G1 Interaction. bioRxiv. 2023 Oct 15doi: https://doi.org/10.1101/2023.10.14.562322.*Joint senior authors

Naeli P, Zhang X, Snell PH, Chatterjee S, Kamran M, Ladak RJ, Orr N, Duchaine T, Sonenberg N, Jafarnejad SM. The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression. J Cell Sci. 2023 Oct 1;136(19):jcs261286. 

Escós A, Diaz-Mora E, Pattison M, Fajardo P, González-Romero D, Risco A, Martín-Gómez J, Bonneil É, Sonenberg N, Jafarnejad SM, Sanz-Ezquerro JJ, Ley SC, Cuenda A. p38γ and p38δ modulate innate immune response by regulating MEF2D activation. Elife. 2023 Jul 17;12:e86200. 

Accogli A, Lin SJ, Severino M, Kim SH, Huang K, Rocca C, Landsverk M, Zaki MS, Al-Maawali A, Srinivasan VM, Al-Thihli K, Schaefer GB, Davis M, Tonduti D, Doneda C, Marten LM, Mühlhausen C, Gomez M, Lamantea E, Mena R, Nizon M, Procaccio V, Begtrup A, Telegrafi A, Cui H, Schulz HL, Mohr J, Biskup S, Loos MA, Aráoz HV, Salpietro V, Keppen LD, Chitre M, Petree C, Raymond L, Vogt J, Sawyer LB, Basinger AA, Pedersen SV, Pearson TS, Grange DK, Lingappa L, McDunnah P, Horvath R, Cognè B, Isidor B, Hahn A, Gripp KW, Jafarnejad SM, Østergaard E, Prada CE, Ghezzi D, Gowda VK, Taylor RW, Sonenberg N, Houlden H, Sissler M, Varshney GK, Maroofian R. Clinical, neuroradiological, and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genet Med. 2023 Jul 13;25(11):100938.

Chalkiadaki K, Statoulla E, Zafeiri M, Haji N, Lacaille JC, Powell CM, Jafarnejad SM*, Khoutorsky A*, Gkogkas CG*Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1. Front Cell Dev Biol. 2023 May 24;11:1205112. *Joint senior authors

Hoang HD, Naeli P, Alain T, Jafarnejad SM. Mechanisms of impairment of interferon production by SARS-CoV-2. Biochem Soc Trans. 2023 May 18:BST20221037. doi: 10.1042/BST20221037.

Hoang HD, Said A, Vaidya N, Gilchrist VH, Malone K, Kabilan U, Topshee S, Xiang X, Yang AD, Olagnier D, Mossman K, Beug ST, Jafarnejad SM, Workenhe ST, Graber TE, Alain T. Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1. J Immunother Cancer. 2023 Mar;11(3):e006408. doi: 10.1136/jitc-2022-006408.

Anadolu MN, Sun J, Kailasam S, Chalkiadaki K, Krimbacher K, Li JT, Markova T, Jafarnejad SM, Lefebvre F, Ortega J, Gkogkas CG, Sossin WS. Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association. J Neurosci. 2023 Apr 5;43(14):2440-2459. doi: 10.1523/JNEUROSCI.1002-22.2023. Epub 2023 Feb 27.

Chalkiadaki K, Hooshmandi M, Lach G, Statoulla E, Simbriger K, Amorim IS, Kouloulia S, Zafeiri M, Pothos P, Bonneil É, Gantois I, Popic J, Kim SH, Wong C, Cao R, Komiyama NH, Atlasi Y, Jafarnejad SM*, Khoutorsky A*, Gkogkas CG*. Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1. Brain. 2023 May 2;146(5):2175-2190*Joint senior authors

 

2022

Escós A, Martín-Gómez J, González-Romero D, Díaz-Mora E, Francisco-Velilla R, Santiago C, Cuezva JM, Domínguez-Zorita S, Martínez-Salas E, Sonenberg N, Sanz-Ezquerro JJ, Jafarnejad SM, Cuenda ATPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with TPL2 mRNA. PNAS. 2022 Aug 30;119(35):e2204752119.

 doi: 10.1073/pnas.2204752119. Epub 2022 Aug 22.

Xu Z, Choi JH, Dai DL, Luo J, Ladak RJ, Li Q, Wang Y, Zhang C, Wiebe S, Liu ACH, Ran X, Yang J, Naeli P, Garzia A, Zhou L, Mahmood N, Deng Q, Elaish M, Lin R, Mahal LK, Hobman TC, Pelletier J, Alain T, Vidal SM, Duchaine T, Mazhab-Jafari MT, Mao X, Jafarnejad SM*, Sonenberg N*. SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translationPNAS. 2022 Aug 9;119(32):e2204539119. doi: 10.1073/pnas.2204539119. *Joint senior authors

Naeli P, Winter T, Hackett AP, Alboushi L, Jafarnejad SM. The intricate balance between microRNA-induced mRNA decay and translational repression. FEBS J. 2022 Mar 5. doi: 10.1111/febs.16422.

Tamaddondoust RN, Wang Y, Jafarnejad SM, Graber TE, Alain T. The highs and lows of ionizing radiation and its effects on protein synthesis. Cell Signal. 2022 Jan;89:110169.

2021

Alboushi L, Hackett A, Naeli P, Bakhti M, Jafarnejad SM. Multifaceted control of mRNA translation machinery in cancer. Cell Signal. 2021 May 8:110037.

Mayya VK, Flamand MN, Lambert AM, Jafarnejad SM, Wohlschlegel JA, Sonenberg N, Duchaine TF. microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development. Nucleic Acids Res. 2021 May 21;49(9):4803-4815.

Zhang X, Chapat C, Wang P, Choi J, Li Q, Luo J, WiebeS, Kim SH, Robichaud N, Karam IF, Dai d, Hackett AP, Lin R, Alain T, Yang L*, Jafarnejad SM*, Sonenberg*. microRNA-mediated translational control of antiviral immunity by the cap-binding protein 4EHP. Molecular Cell 2021 Feb 9:S1097-2765(21)00050-2. *Joint senior authors

Simbriger K, Amorim IS, Lach G, Chalkiadaki K, Kouloulia S, Jafarnejad SM*, Khoutorsky A*, Gkogkas CG*. Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling. Progress in Neurobiology. 2021 Feb;197:101903. *Joint senior authors

2020

Kim SH, Choi JH, Wang P, Go CD, Hesketh GG, Gingras AC, Jafarnejad SM*, Sonenberg N*. Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation. Molecular Cell. 2020 Dec 10:S1097-2765(20)30836-4. PMID: 33340489. *Joint senior authors

 

Mousavizadeh R, Hojabrpour P, Eltit F, McDonald PC, Dedhar S, McCormack RG, Duronio V, Jafarnejad SM, Scott A. β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells. Sci Rep. 2020 Jul 28;10(1):12644.

 

Atlasi A*, Jafarnejad SM*, Gkogkas CG, Vermeulen M, Sonenberg N, Stunnenberg HG. The translational landscape of ground state pluripotency. Nature Communications. 2020 Apr 1;11(1):1617. PMID: 32238817. *Joint first authors

Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A, Gkogkas CG. Monitoring translation in synaptic fractions using a ribosome profiling strategy. J Neurosci Methods. 2020 Jan 1;329:108456.

2019

Hoang HD, Graber TE, Jia JJ, Vaidya N, Gilchrist VH, Xiang X, Li W, Cowan KN, Gkogkas CG, Jaramillo M, Jafarnejad SM, Alain T. Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection. Cell Reports. 2019 Dec 17;29(12):4010-4023.e5.

Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A, Gkogkas CG. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Reports. 2019 Dec 10;29(11):3620-3635.e7. 
 

Hassanzadeh G, Naing T, Graber T, Jafarnejad SM, Stojdl DF, Alain T, Holcik M. Characterizing Cellular Responses During Oncolytic Maraba Virus Infection. International Journal of Molecular Sciences. 2019 Jan 29;20(3). pii: E580.

2018

Uttam S, Wong C, Amorim IS, Jafarnejad SM, Tansley SN, Yang J, Prager-Khoutorsky M, Mogil JS, Gkogkas CG and Khoutorsky A. Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiology of Pain Aug-Dec 2018;4:35-44.

Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong TV, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Graber TE, Fonseca BD, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman K, Jaramillo M, Sonenberg N, Alain T. Active-Site mTOR Inhibitors Augment HSV1 Infection of Cancer Cells with Elevated eIF4E Activity. PLOS Pathogens. 2018 Aug 23;14(8):e1007264.

Jafarnejad SM*, Chapat C*, Matta-Camacho E, Gelbart IA, Gkogkas CG, Meztli Arguello, Garzia A, Kim S, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tushcl T, Gingras AC, Duchaine TF, Sonenberg N. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife. 2018 Feb 7;7. pii: e35034. *Joint first authors

Amorim IS, Kedia S, Kouloulia S, Gantois I, Jafarnejad SM, Simbriger K, Li Y, Kampaite A, Pooters T, Romanò N, Khoutorsky A, and Gkogkas CG. Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation. J. Neuroscience. 2018 Feb 21;38(8):2118-2133.

Jafarnejad SM*, Kim SH*, Sonenberg N. Aminoacylation of proteins; new targets for the old ARSenal. Cell Metab. 2018 Jan 9;27(1):1-3. *Joint first authors

2017

Garzia A*, Jafarnejad SM*, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nature Communications. 2017 Jul 7;8:16056. *Joint first authors

 

Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Nagpal A, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Metformin ameliorates core deficits in a Fragile X syndrome mouse model. Nature Medicine. 2017 Jun;23(6):674-677.  

 

Chapat C*, Jafarnejad SM*, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. The cap-binding protein 4EHP effects translation silencing by microRNAs. PNAS. 2017 May 23;114(21):5425-5430. *Joint first authors

2016

Tahmasebi S*, Jafarnejad SM*, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. PNAS. 2016 Nov 1;113(44):12360-12367. *Joint first authors

 

Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. eIF2α phosphorylation controls thermal nociception. PNAS. 2016 Oct 18;113(42):11949-11954.

 

Chio IIC, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Filippini D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia JM, DeNicola GM, Tiriac H, Hammell M, Crawford HC, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell. 2016 Aug 11;166(4):963-76.

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