We use state-of-the-art high-throughput technologies in combination with cell & molecular biology approaches to address important question in mechanisms of regulation of mRNA translation and decay and their role in complex diseases such as cancer.

 

Regulation of mRNA translation and decay is an integral part of the gene expression programme. As such, dysregulated mRNA translation and decay machineriers play key roles in maintenance and progression of cancers, evidence by development of numerous drugs that target these mechanisms and are in various stages of clinical trials or in clinical use.

 

Recent advances in mRNA vaccine technology, exemplified by the spectacular succes of the SARS-CoV2 mRNA vaccines, also highlight the importance of further research into the cellular mechanisms that control mRNA translation and decay to develop more potent treatments and improving upon the existing mRNA technologies.